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Treatment with pioglitazone as add-on to metformin produced statistically significant improvements in HbA1c and FPG at endpoint compared to placebo add-on to metformin (see Table 22).

Overall, no increase in breast cancer rates was associated with insulin glargine use, although patients who used only insulin glargine had a higher rate of cancer than did those who used another type of insulin.

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The mechanism for increased death associated with these antipsychotics is not completely understood, and there were limitations in the methodology of each study.

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