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How long can you stay on tamoxifen? take tamoxifen for 5 years, then switch to an aromatase inhibitor for another 5 years (for a total of 10 years of hormonal therapy)
How long does it take to get Tamoxifen out of my system? The half-life of tamoxifen (the period of time required for the concentration or amount of drug in the body to be reduced by one-half) is about 7 days.
Does tamoxifen cause liver issues? According to meta-analysis, consecutive 5-year tamoxifen treatment can reduce mortality rate by 31%. Even though it is well tolerated, several side effects are inevitable, and fatty liver is one of the most common side effects among these.

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