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Commission on Human Medicines CHM looked at the data and concluded that these side effects cannot be ruled out even when diclofenac is taken for a short time or at a lower dose, and advised that it is no longer suitable as a P medicine.
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Patients already on ACE inhibitor or angiotensin receptor blocker ARB therapy had to take a stable dose of ACE inhibitor or ARB equivalent to enalapril 10 mg daily and a betablocker for at least 4 weeks prior to the trial.
The author declares no conflicts of interest.
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